(DOWNLOAD) "Adiponectin and Leptin in Maternal Serum, Cord Blood, And Breast Milk (Pediatric Clinical Chemistry)" by Clinical Chemistry * Book PDF Kindle ePub Free
eBook details
- Title: Adiponectin and Leptin in Maternal Serum, Cord Blood, And Breast Milk (Pediatric Clinical Chemistry)
- Author : Clinical Chemistry
- Release Date : January 01, 2006
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 214 KB
Description
Adiponectin and leptin are members of the adipose-secreted proteins termed adipocytokines or adipokines. Leptin was discovered as a protein involved in the development of obesity, and although it is now recognized as a hormone that is produced by several tissues, adipose tissue is the principal site of leptin production and the major determinant of the concentration of circulating hormone (1). Adiponectin, discovered in 1995, is postulated to play a role in the modulation of glucose and lipid metabolism in insulin-sensitive tissues. Plasma adiponectin concentrations exceed those of any other hormone by a factor of 1000 and decrease in insulin-resistant states, including type 2 diabetes mellitus, suggesting a positive relationship to whole-body insulin sensitivity (2). Recent findings have indicated that adiponectin has antiatherogenic properties and antiinflammatory effects (3). In addition to regulation of whole-body metabolism, leptin and adiponectin are known to be produced within the intrauterine environment (4-9). The findings that leptin and adiponectin are present in cord blood and the positive correlation of their concentrations with neonatal birth weight (10-13), as well as the high production of both leptin and adiponectin in the placenta and the fetus, suggest that these adipokines may play key roles in fetal development (14,15). Furthermore, adipokines are potent regulators of the immune response and are possible risk determinants for many diseases that may involve dysregulation of the immune response, such as asthma, obesity, and other inflammatory conditions (16).